A sequel to 2000's The Skulls, The Skulls II once again delves into the world of a secret Ivy League society known as the Skulls (loosely based on Yale's Skull and Bones fraternity).

Here, new inductee Ryan Sommers (Dunne) faces a dilemma when, soon after having taken an oath not to betray any of the society's secrets or its powerful members, he witnesses a murder inside the Skulls' private chambers. Pressured by the authorities and convinced that his brothers in the Skulls are watching him, Ryan must decide between telling the truth or dealing with the wrath of his increasingly menacing brothers.