Phineas and Ferb team up with the Marvel Super Heroes (Spider-Man, Iron Man, Thor, and the Hulk), to help them regain their powers and defeat Marvel Super Villains Red Skull, Whiplash, Venom, and M.O.D.O.K. who are working together with Dr. Doofenshmirtz and his scheme to use his power-draining technology to create mayhem. The heroes enter the world of Danville to relocate their powers, defeat the Marvel Villains- who have also shown up to seal Doofenshmirtz's power-draining technology and save Danville from ultimate destruction!