When charismatic Chief of Surgery Charlie Harris of Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos – and his fiancée and fellow surgeon, Alex Reid in a state of shock.

Along with newly-arrived star surgeon, Joel Goran, Alex and her fellow doctors press on to save Charlie's life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.