In Upstate New York, Irene (Vera Farmiga) struggles to raise two sons, keep her stale marriage together and manage a secret cocaine habit. Isolated by the strip malls and dying small towns that define the area, Irene's not sure when she went from high school partying to skimming off the grocery store money to supply her growing habit - but its about to end abruptly.

Desperate to alter her life, she puts herself in rehab, hoping that she can turn around the world she has made with her husband, Steve (Clint Jordan). But once she's back home the distance between them seems to have grown and Irene ends up falling into an incendiary affair with Bob (Hugh Dillon), a nurse and former addict that she met at rehab.

His attention and affection awakens her pushed aside life, but all too soon she realises they have more in common than she bargained for.