The thrilling Dollhouse reunites Buffy The Vampire Slayer creator Joss Whedon (Firefly, Serenity) and Eliza Dushku (Angel). Echo is an 'Active' - someone whose memories have been wiped and replaced. Hired for nefarious gains, she acts with no memory of before. Can she rediscover her true identity before it's too late?

Confined between missions to a secret facility known as the "Dollhouse," Echo and the other Actives including Sierra (Dichen Lachman), are assigned engagements by Adelle Dewitt (Olivia Williams), one of the Dollhouse leaders. After each scenario, Echo, always under the watchful eye of her handler, Boyd Langton (Harry Lennix), returns to the mysterious Dollhouse where her thoughts, feelings, experiences and knowledge are erased by Topher Brink (Fran Kranz), the Dollhouse's genius programmer.